Yummy! I got a real live anti-ager to react to the idea that one day follows another. Kevin Perrott is the CEO
of AgeNet an organization that aspires to conquering normal human aging. He sounds like a really nice guy and he posted a comment in response to THIS.
Want to know what I think?
Here we go!
Bill Thomas says: “Even though aging is hard-wired into our DNA we persist in thinking of aging as if it was a technical problem.” You would be hard pressed to find a single scientist who studies the basic biological mechanisms of aging to agree that aging is “hard-wired into our DNA”.
Actually, the google took a thousandth of a second to find this…
The role of genetic factors in the determination of lifespan is undisputed. However, numerous successful efforts to identify individual genetic modulators of longevity have not yielded yet a quantitative measure to estimate the lifespan of a species from scratch, merely based on its genomic constitution. Here, we report on a meta-examination of genome sequences from 248 animal species with known maximum lifespan, including mammals, birds, fish, insects, and helminths.
Emphasis mine, much more HERE
For those who are less scientifically inclined, I found this on an ANTI-AGING website…
Ever hear of a man by the name of Jack LaLanne? If you’re over 40 or concerned with fitness or aging, the chances are you know exactly who he was. Jack Lalane was best known as one of the earliest fitness and nutrition gurus. As a chiropractor and fitness trainer, he was a wellness pioneer and promoted physical exercise and eating healthy fresh juiced vegetables and fruits. His late night infomercials promoting his juicer and the miracles of juicing were memorable. In fact, to prove his point, he staged incredible endurance and strength events. Most notable, he swam great distances while pulling multiple boats with a rope in his mouth and his hands bound. On January 23, 2011, however, this great health advocate passed at 96-years young. Let’s take a moment and give him a round of applause please. He lived his message and was in great condition until he passed.
For the purposes of this longevity discourse, the hard question at hand is, “did his approach work in regards to slowing or reversing the aging process and did he look younger than the average 96 year-old person?”
Surely, he lived beyond the national average life span, but in my opinion, he did not look any younger. He looked fit, a fit ninety-something-year-old man. Although he was still very active in his nineties, his body just wore out and he fell to pneumonia.
The reason that Jack LaLanne, who was an awesome specimen of humanity, did not live to be 435 years old is that the human lifespan– like the lifespan of all living things is encoded into our DNA. When was the last time you heard of a dog living to be 139 years old? Dogs also have a finite lifespan and its duration is written into its DNA.
Aging is normal!
There is no need to have it hard-wired, falling apart is the default, evolutionarily speaking. Our systems are designed to “hold back the tide” and fight entropy only hard enough to allow us to have children and raise them to have children after which we are basically done and our systems have degenerated to the point where we begin to visibly age.
This is actually a powerful and insightful observation. One of the most important things that separates humanity from other living creatures is that human beings have found an adaptive advantage in extending life beyond senescence. We age better than any other creature on earth because we have amplified the virtues of aging.
Aging *is* a technical problem, as anyone who is losing function knows all too well. “Technically” we can no longer climb stairs, control our elimination, think clearly, and on and on… if it isn’t “technical” it certainly is a “PROBLEM”.
Oh yes, it is true— not being able to climb stairs is a problem. Not being able to climb 86 flights of stairs is also a problem. Not being able to climb to the top of the Empire State faster than anyone else is an even bigger problem.
Hundreds of runners felt on top of the world after racing to the 86th floor of the Empire State Building Tuesday. German engineering student Thomas Dold was the fastest person to climb the 1,576 steps, in a speedy 10 minutes, 10 seconds. Australian medical student Alice McNamara won the women’s event in 13 minutes, 3 seconds. “To climb to the top of New York – the greatest city in the world – is just fantastic,” she said.
“It’s definitely one of the toughest things I’ve ever done,” added the 24-year-old, who has four world championship rowing titles to her name and is vying for a spot on her country’s Olympic team.
Thirty year old people have a TECHNICAL problem— they simply cannot compete with people in their early 20’s when it comes to climbing to the top of the Empire State building. They are aging!
It is OK that they are aging– we understand that this is a normal phenomenon. Indeed the very idea of a “normal” physical capacity is age normative. When 80 year olds start winning the race to the top of the Empire State building, I will start listening to the Anti-Aging gurus.
Until then, not so much.
New science is providing evidence that the aging process itself may be amenable to pharmacological intervention with drugs such as rapamycin and other mTOR inhibitors, starting when already “old”.
Proof please! (smile)
This will allow people to stay healthy longer and solve a bit of that “technical problem” Thomas refers to.
Proof please! (smile)
Other science in regenerative medicine, promises to not just slow degenerative disease down, but restore the function lost to it.
Actually, we have been “restoring function” for a very long time. There is an entire branch of medicine that is based on “restoring function.” It is called “physiatry” and I love it.
These advances promise greater healthy independence for longer periods of time, allowing people to continue to contribute to their communities and lead more productive lives.
I also hope for, work for and believe in “greater healthy independence for longer periods of time.” This is a good thing. I believe in a common sense and evidence-based approach to this challenge. Many other people believe in magic and smoke and mirrors.
Mr. Thomas might wish to examine the progress in such technologies that maintain and restore function, they are what are really needed, not some nostalgic acceptance of some imagined “hard-wired” process that doesn’t exist.
I am a physician and my life has been dedicated to helping improve the lives of older people and when evidence emerges that new technologies are capable of “stopping and reversing aging” and “making youth permanent” I will be the first to champion them. When anti-aging proves that it is able to undo the aging process to which 56 billion human beings over the course of human history have all, without exception, been subject I will proclaim the news from every roof top!
Until then, I will use common sense and a healthy respect for aging and our ultimate mortality as signposts that can, with good fortune at my side, guide me to a life worth living.